What the National Cancer Institute says about Annonaceous acetogenins

Definition of Annonaceous acetogenins is from the National Cancer Institute’s website Cancer.gov

The original text from the NCI defintion is below:

“A family of naturally occurring polyketides  that consist of C32 or C34 long chain fatty acids and combined with a propan-2-ol unit at C-2 to form a gamma-lactone which are isolated from various species of the plant family Annonaceae with potential antineoplastic and antimicrobial activity. Annonaceous acetogenins bind to the ubiquinone catalytic site(s) within the mitochondrial NADH:ubiquinone oxidoreductase (complex I), and block the electron transport chain in mitochondria. In addition, the acetogenins bind to and block the activity of ubiquinone-linked NADH oxidase, an enzyme overexpressed in the plasma membranes of cancer cells. This inhibits adenosine triphosphate (ATP) production, decreases intracellular ATP levels, and induces tumor cell apoptosis. Compared to normal cells, cancer cells have higher ATP demands. The Annonaceous acetogenins also inhibit microbial glucose dehydrogenase 6.”

Now for the average person that is a lot to digest, so let’s break it down even further:

A family of naturally occurring polyketides…

Polyketides are natural metabolites (byproducts in a chemical reaction that produces energy in a living thing) that comprise the basic chemical structure of various anticancer, antifungal, and anticholesteremic agents; antibiotics; parasiticides and immunomodulators. The sales of pharmaceuticals derived from polyketides routinely reaches $20 billion annually.

…that consist of C32 or C34 long chain fatty acids and combined with a propan-2-ol unit at C-2 to form a gamma-lactone…

  • C32 and C34 are two types of fatty acids. Fatty acids are common in food consumed by humans and animals because when eaten it provides energy to cells.
  • Propan-2-ol is a a type of alcohol.
  • So a fatty acid interacts with an alcohol to  produce

…which are isolated from various species of the plant family Annonaceae…

Annonaceae is a scientific classification term that refers to a plant family that has 2400 species, but is primarily known as the “custard apple” family.  The plant family is found primarily in tropical regions around the world. Within this family is Annona muricata, which is more commonly known in every English as soursop or graviola. In Spanish, it is known as guanabana.

…with potential antineoplastic and antimicrobial activity.

Antineoplastic activity: Activity that prevents, inhibits or halts the development of a tumor.

Antimicrobial activity: Activity that kills microorganisms or stops their growth. e.g. An antibiotics’ antimicrobial activity results in killing bacteria.

...Annonaceous acetogenins bind to the ubiquinone catalytic site(s) within the mitochondrial NADH:ubiquinone oxidoreductase (complex I) and block the electron transport chain in mitochondria.

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In addition, the acetogenins bind to and block the activity of ubiquinone-linked NADH oxidase, an enzyme overexpressed in the plasma membranes of cancer cells.

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This inhibits adenosine triphosphate (ATP) production, decreases intracellular ATP levels, and induces tumor cell apoptosis. Compared to normal cells, cancer cells have higher ATP demands. The Annonaceous acetogenins also inhibit microbial glucose dehydrogenase 6.

 

 

 

moringa

About Moringa Oelifa Tea

We received a lovely email from Paula, who is also a soursop leaves customer of http://soursopstore.com.

She told us a wonderful story about a young 8-year-old girl, who had leukemia and was being treated with chemotherapy. Paula also shared a special recipe she received from MiLottie’s parents received from South American missionaries.

They had heard about soursop leaves, and so their church reached out to the missionaries.  They responded by sending the leaves with instructions on how to brew a very special remedy.

Lottie’s parents started giving her one cup three times per day along with Anamu and Moringa Oleifera tea from leaves. Anamu helped with pain. Moringa boosted with energy. Soursop leaves are used by people with cancer (see soursop cancer research).

“Lottie was a different child in two weeks and totally healed from Leukemia. The Lord led them from beginning to end. The body starts to feel the effect of heat, similar to the effect of chemo but no side effects,” said Paula.

What is corossol fruit?

Soursop fruit

Corrosol fruit is yet another name for soursop fruit.  Soursop is a spiny tropical fruit with a sweet custardy pulp that grows in the Caribbean, in South America, and in equatorial regions of the world. In the U.S., you can buy soursop products online at http://soursopstore.com. In Canada, you can order soursop products from http://soursopstore.ca.

Learn more about: What is soursop

Corrosol is a French word that translates to Soursop.

Here are a bunch of other words in various languages that translate to soursop in English or corrosol in French. See below:

 

Soursop / Corrosol wordsLanguageCountry/Region
قشطة شائكة .ArabicSaudia Arabia and region​
soursop, graviolaEnglishUSA, UK, Canada
zuurzak, zuurzakvrucht, zuurzakboom, zuurzakkenDutchNetherlands
Guanabana, Stachelannone, SauersackGermanGermany
atɔEweGhana
γουανάμπαναGreekGreece
yaca, guanábano, guanábana, chirimoyaSpanishSpain, Mexico, Latin America, S. America
corossol, corossolierFrenchFrance, Canada (Quebec)
חמוצהHebrewIsrael
सीताफल Hindi IndiaHindiIndia
pohon sirsak, buah sirsak, sirsak Indonesian Indonesia
guanabana, graviolaItalianItaly
ຂຽບLaoLaos
サワーサップJapaneseJapan
사워 sKoreanKorea
durian belandaMalayMalaysia
سورسPersianIran, Tajikistan, Uzbekistan, Iraq, Russia, Azerbaijan and Afghanistan
graviolaPortuguesePortugal
soursopNorwegian Norway
сауасе́п, саусе́п, анно́на колю́чая, смета́нное я́блоко, соуса́пRussianRussia
ทุเรียนเทศThaiThailand
guyabanoTagalogPhilippines
soursopUrdu Pakistan
bình bát, nêVietnameseVietnam
刺果番荔枝ChineseChina

Where to buy freeze dried soursop?

Freeze dried soursop is increasingly available in the U.S. and Canada.

The tropical fruit travels well when it is freeze dried and cost to ship it is low because the water has been removed from the product.

You can order it from several online retailers: